Dr. Shireen Guide completed her internship and attended medical school at Stanford University Medical School. She completed her dermatology residency at University of Texas, Southwestern. She served her pediatric dermatology fellowship at University of California, San Diego.  She has completed a clinical research fellowship at the National Institutes of Health. ​

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Dr. Guide has authored numerous journal publications related to her research, as well as several chapters in prominent textbooks, including Fitzpatrick's Dermatology in General Medicine 2003 (6th Edition) and the Clinics of North America series. In addition, she has contributed to annual publications of the Dermatology Yearbook and continues to review articles for pediatric dermatology journals. She has presented at several conferences including the American Academy of Dermatology and San Diego's 2011 Pediatric Dermatology for the Practitioner. She serves as an expert witness for the California medical board and Cooperative of American Physicians. Frequently, Dr. Guide provides community service through  free melanoma nd skin cancer screenings, recognized by the American Academy of Dermatology. She has performed volunteer services as a translator for the Smithsonian, and as a camp counselor for children with skin diseases. 

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In her free time, Dr. Guide instills the importance of sun education in her husband and three children. She enjoys family outings at some of their favorite spots, including the Aquarium, Sea World, Wild Animal Park, and the Discovery Museum.